All biomanufacturing routes are addressable
CASE STUDY 1: FERMENTATIVE BIOSYNTHESIS OF SMALL MOLECULES
14,000x improvement in Lysine production in E. coli
- 200,000 edits for parallel engineering of enzymes, pathway and genome
- 19 pathway enzymes
- Genome-wide knockouts
- Genome-wide 5X promoter ladder
- 18,000 single edit-containing strains screened in HTP
- Rapid Fire MS analysis at 7 sec/sample
- Large numbers of advantageous edits identified in every library type
- Combining just 3 advantageous edits provided 14,000x improvement in productivity
- Lean Bioengineering™
- Rapid and low-cost process: 4 months
Hit rankings from high throughput (HTP) scale were maintained, demonstrating robust HTP screening and analysis processes.
Peak Lysine titers reached >10 g/L
No random mutations to impact strain fitness in stirred-tank reactors
CASE STUDY 2: BIOCONVERSION PROCESS FOR SMALL MOLECULES
Three-enzyme pathway in E. coli for bioconversion
Wide range of biology implicated in improving bioconversion
CASE STUDY 3: FERMENTATIVE PRODUCTION OF LARGE MOLECULES
Improved protein production across hosts
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